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Disclosure - Debt - Debt maturities (Details) link:presentationLink link:calculationLink link:definitionLink 99940901 - Disclosure - Stockholders equity (deficit) (Details) link:presentationLink link:calculationLink link:definitionLink 99941001 - Disclosure - Stock compensation plans - 2021 Equity Incentive Plan (Details) link:presentationLink link:calculationLink link:definitionLink 99941002 - Disclosure - Stock compensation plans - 2015 Equity Incentive Plan (Details) link:presentationLink link:calculationLink link:definitionLink 99941003 - Disclosure - Stock compensation plans - Summary of option activity (Details) link:presentationLink link:calculationLink link:definitionLink 99941004 - Disclosure - Stock compensation plans - Stock Options (Details) link:presentationLink link:calculationLink link:definitionLink 99941005 - Disclosure - Stock compensation plans - Restricted Stock Units (Details) link:presentationLink link:calculationLink link:definitionLink 99941006 - Disclosure - Stock compensation plans - Stock-based compensation expense and unrecognized compensation cost (Details) link:presentationLink link:calculationLink link:definitionLink 99941101 - Disclosure - Employee stock purchase plan (Details) link:presentationLink link:calculationLink link:definitionLink 99941201 - Disclosure - Income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 99941202 - Disclosure - Income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 99941207 - Disclosure - Income taxes - Rollforward of uncertain tax positions related to research and development tax credits (Details) link:presentationLink link:calculationLink link:definitionLink 99941301 - Disclosure - Commitments and contingencies - License Agreements (Details) link:presentationLink link:calculationLink link:definitionLink 99941302 - Disclosure - Commitments and contingencies - Changes in fair value of long-term portion of contingent consideration (Details) link:presentationLink link:calculationLink link:definitionLink 99941402 - Disclosure - Net loss per share attributable to common stockholders - Antidilutive shares (Details) link:presentationLink link:calculationLink link:definitionLink 99941501 - Disclosure - Segments - Revenue and expenses (Details) link:presentationLink link:calculationLink link:definitionLink 99941502 - Disclosure - Segments (Details) link:presentationLink link:calculationLink link:definitionLink 99941503 - Disclosure - Segments - Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 99941601 - Disclosure - Related party transactions (Details) link:presentationLink link:calculationLink link:definitionLink 99941701 - Disclosure - Leases - Impairment Charges (Details) link:presentationLink link:calculationLink link:definitionLink 99941703 - Disclosure - Leases - Office and warehouse leases (Details) link:presentationLink link:calculationLink link:definitionLink 99941706 - Disclosure - Leases - Weighted-average remaining lease term, incremental borrowing rate, and supplemental cash flow information (Details) link:presentationLink link:calculationLink link:definitionLink 99941801 - 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